RELATION BETWEEN CHRONIC RHINOSINUSITIS AND SERUM VITAMIN D3 LEVEL

Abstract

Objectives: 
To explore the relation between Chronic rhinosinusitis (CRS) and serum Vitamin D3 level.
Materials and methods:
A prospective, observational study consisting of 115 patients with CRS was carried out at Department of ENT & HNS in Bir Hospital from March 2018 to March 2019. Patients were divided into two groups: ‘CRSwNP (Chronic rhinosinusitis with polyp)’ and ‘CRSsNP (Chronic rhinosinusitis without polyp).’ Vitamin D3 levels were measured by Chemiluminescent Immunoassay method and compared between the two groups. Receiver operating characteristic (ROC) curve analysis was also performed to evaluate the role of vitamin D3 in discriminating between the two groups.
Results: 
Out of 115 cases, 54 (47%) had CRSwNP and 61 (53%) had CRSsNP. Mean age of the patients was 34.7 years. Sixty six (57%) were female. Mean vitamin D3 level of all patients was 23.86 ng/ml. Only 17 (14.8%) patients had normal vitamin D3 level. CRSwNP patients had significantly lower vitamin D3 levels compared to CRSsNP patients (21.42 ng/ml vs. 26.01ng/ml respectively; p value <0.001). Higher proportion of patients with CRSwNP had Vitamin D3 deficiency compared to CRSsNP cases (35.2% vs. 16.4%). On ROC curve analysis of Vitamin D3 to discriminate CRSsNP from CRSwNP, area under the curve (AUC) was 0.718 and accuracy was 67.83% at a cutoff value of ≥ 23.15 ng/ml.
Conclusion: 
The mean vitamin D3 levels in CRSwNP patients was significantly lower than CRSsNP patients. A cut off level of vitamin D3 level ≥23.15ng/ml had a fair ability to discriminate CRSsNP patients from CRSwNP patients.
Keywords: Chronic Rhinosinusitis (CRS), Polyp, Task force criteria, Vitamin D3.